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A key mechanism underlying their effectiveness is delayed gastric emptying

A large cardiovascular outcomes trial found that higher proportions of tirzepatide recipients reported vomiting, diarrhea, and nausea compared to those taking a selective GLP-1RA

Compound drugs are copies of U.S

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[175] An analysis of events in the US FDA Adverse Event Reporting System suggests an association between several GLP-1 agonists (including semaglutide) and cutaneous reactions, such as dermal hypersensitivity reactions, eosinophilic panniculitis, bullous pemphigoid, and morbilliform drug eruptions