The downregulation of myeloid zinc finger 1 (MZF1) expression, which activates the Nrf2/GPX4 pathway and inhibits rankl-induced ferroptosis in osteoclasts during early cell differentiation, may be a key mechanism underlying ovarian removal (OVX) mice models of postmenopausal osteoporosis (37)
3.3.3 Polyphenols and flavonoids Polyphenols are a class of compounds with significant antioxidant activity, specifically divided into flavonoids and non-flavonoids
This allows for higher concentrations of nutrients and ensures optimal absorption, especially for those with compromised gut health
Studies in bleomycin-induced pulmonary fibrosis show GHK administration at 2.6-260 g/mL/day reduces pathological TGF-1, preventing harmful fibrosis while maintaining beneficial tissue repair signals
Conclusions GLP-1 RAs seem to adversely affect gut motility, with an increased risk of RGCs during upper endoscopy (without a simultaneous increase in aspiration risk), inadequate bowel preparation during colonoscopy, and incomplete passage through the small intestine during capsule endoscopy