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Li, Yiwei, and Fazlul H
In addition to being a powerful antioxidant, glutathione also inhibits the production of pro-inflammatory cytokines
They also found that in human keratinocytes, apigenin treatment (20 M) had no cytotoxic effects and induced filaggrin, loricrin, aquaporin-3, hyaluronic acid (HA) and HA synthase (HAS)-1, -2, and -3, which constitute physical barrier of the skin [135]
Moreover, existing data indicate that single-target GLP-1RAs such as SEMA and liraglutide show promising capabilities for fibrosis improvement, and the initial success of the dual agonist tirzepatide suggests potential benefits of dose titration therapy in the monotherapy management of MASLD
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