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Clinical Trials on Dual GLP-1/GIP Agonists Tirzepatide: Combining GLP-1 and GIP for Enhanced Weight Loss Tirzepatide is a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist developed to enhance weight loss beyond that achieved with GLP-1 receptor agonist monotherapy

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Weve got to figure out whats the right way of [providing GLP-1 pills] in all these different circumstances, he says.

Novos Wegovy and Lillys Zepbound are mentioned in the organizations new guidelines as drugs that should be considered when the goal is to prevent cardiovascular disease

Natural GLP-1 has a half-life of only about 2 minutes, because an enzyme called DPP-4 rapidly breaks it down