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doi:10.1016/j.bcp.2012.07.018 Rondanelli M, Riva A, Petrangolini G, et al

The trial lasted 68 weeks and included 3417 individuals who were randomized to either CagriSema, its individual components or placebo [125]

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The molecular structure explains why this step is rate-limiting: the steric bulk of the branched alcohol and the hydrophobicity of the diester slow water access to the ester carbonyl, and the reaction is enzyme-catalysed rather than spontaneous

However, larger and longer-term studies are needed to confirm these findings