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Additionally, GLP-1 RAs exhibit neuroprotective and anti-inflammatory effects, increase Akt dephosphorylation, decrease proinflammatory factors such as TNF-, elevate neurotrophic factors like BDNF, reduce oxidative stress and microglial activation, and enhance gut-brain axis function and gut microbiota stability [176]

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Receptor activation triggers intracellular calcium release through phospholipase C and inositol trisphosphate (IP3) signaling, which causes GH-containing secretory granules to fuse with the cell membrane and release their contents into the bloodstream

Androgen receptor (AR) targeted therapy is particularly effective in a subset of patients with TNBC that express AR

Modig, K., Pfrommer, B