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Collectively, these data suggest that eosinophils play a critical role in maintaining an anti-inflammatory, M2-skewed macrophage environment in the inflamed skin

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Cells (2019) 8:E818

The transcription factor WRKY75 further amplifies this response, upregulating JA pathway genes like ORA59 and PDF1.2 in overexpressing plants, while their expression drops in wrky75 mutants ( S

These changes are associated with significant alterations in gut bacterial and fungal communities, gut barrier function disruption, and enhanced pro-inflammatory responses in mesenteric lymph nodes