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Semaglutide and the other GLP-1 agonists have the added benefit of central effects on the hunger centres in the hypothalamus as well as delaying gastric emptying to increase fullness and suppress appetite, a valuable tool for both the treatment of diabetes and weight loss management, but a potential risk for the use of sedation/anaesthesia

Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress

Yes, thats when GLP-1 (glucagon-like peptide-1) first showed up on scientists radars

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