In preclinical studies, GIPR/GLP-1R co-agonism produces less nauseating effects compared to GLP-1R agonism alone as measured by kaolin intake in mice and rats and emetic events in musk shrews (69)
Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I
Yerba mate may also be protective for your heart, according to 2020 research in Proceedings of the Nutrition Society
Hepatic accumulation of bile acids and phytosterols play a significant role in PNAC pathogenesis
When GLP-1RAs act on the gastrointestinal tract, they could extend the gastric emptying time