Given his results, while I might try just high dose serine first, adding NAC, nicotinamide riboside, glycine and carnitine also makes sense, as Mardinoglus research suggests
Evening administration before bed makes this fasting window easy to achieve for most schedules
Funding: This work was supported by Secretara de Ciencia, Humanidades, Tecnologa, e Inovacin (SECIHTI, before CONACyT, grant CF19-739 awarded to RAZ and AL) and the Direccin General de Asuntos del Personal Acadmico - Programa de Apoyos a Proyectos de Investigacin e Innovacin Tecnolgica, UNAM (DGAPA-PAPIIT, grant IN205422 awarded to AL and grant IN226523 awarded to ERP)
Hart, K
Interestingly, early-stage Alzheimer patients sometimes show elevated serum BDNF, likely as a compensatory mechanism