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Biomaterials 159 , 161173 (2018)

6, June 2012, pp

Mechanisms by which ROS cause cerebral tissue damage are not well understood but ROS are reported to trigger a variety of molecular cascades that increase blood-brain barrier permeability and alter brain morphology, thus causing neuroinflammation, and neuronal death (Gu et al., 2011)

Novo Nordisk filed a New Drug Application for the CagriSema combination (cagrilintide 2.4 mg + semaglutide 2.4 mg) in December 2025, with an FDA decision anticipated in late 2026