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Similarly, GLP-1R activation on the axons from dispersed SPNs in the ICN, and possibly CAA, may account for other, rarer side effects of GLP-1R agonists

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Combining CRISPR/Cas9mediated targeted knockdown of receptors in a specific group of neurons with neural circuit manipulation techniques, we dissected the function of LS GLP-1 receptors and LS GLP-1R neurons and uncovered an essential role for these neurons in physiological satiation, as well as a role in generating liraglutide-induced anorectic and weight-reducing effects

Oral Formulation: Importantly, different formulations of the same medication (e.g., Ozempic, Wegovy, and Rybelsus) are not interchangeable despite containing semaglutide

PMID: 21481449