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Beyond pigmentation-related pathways, MC1R signaling has been implicated in broader cellular processes, including potential anti-inflammatory signaling and the preservation of melanocyte genomic stability

Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors

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"Across five positive Phase III studies, Retatrutide has shown powerful efficacy, and we believe it could be an important future tool in the management of cardiometabolic health," said Kenneth Custer, executive vice president and president of Lilly Cardiometabolic Health