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The gold standard for diagnosis and assessment is a liver biopsy, an invasive procedure

Disclosures: Grace Lai-Hung Wong: AstraZeneca, Gilead Sciences, GlaxoSmithKline and Janssen,: Advisor, Abbott, AbbVie, Ascletis, Bristol-Myers Squibb, Echosens, Gi: Speaking and Teaching, Gilead Sciences: Grant/Research Support, Mario Alvares-da-Silva: Nothing to Disclose, Fatima Higuera-de-la-Tijera: Nothing to Disclose, Ming-Lung Yu: Abbvie, Gilead and Roche diagnostics.: Grant/Research Support, Abbott, Abbvie, Gilead, Roche and Roche diagnostics: Consultant, Abbvie, BMS, Gilead, Roche and Roche diagnostics: Speaking and Teaching, Soo Aleman: Gilead: Speaking and Teaching, Francisco Javier Garca-Samaniego Rey: Gilead

Some patients may require both medications concurrentlyfor example, an adult with ADHD who also meets criteria for specialist weight management

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Adherence is generally affected by a combination of capability (strength, dexterity, cognitive powers), opportunity (complexity, cost, availability) and motivation (intrinsic drivers, rewards, general mood).11 Based on this, it is possible to calculate relative differences in likely adherence with a quantitative analysis of typical disease impact, patient demographics, drug effects and device operating principles.12 By systematically analysing a drug delivery solution, it is possible to identify opportunities for improvement and determine the cost-benefit of investing in a wide range of design features