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Separately, research has examined DSIPs role in stress axis modulation specifically its effects on corticotropin-releasing hormone (CRH) and ACTH secretion suggesting a potential interface between the sleep regulatory system and the hypothalamic-pituitary-adrenal (HPA) axis

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GLP-1 receptors are found in key brain areas like the hypothalamus, hippocampus, and amygdala , which are involved in regulating hunger, mood, and stress

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This may have created an opportunity for falsified/counterfeit products flooding the market claiming to be Ozempic and being used off-label for weight loss