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GLP-1 Drugs Weight Loss Results From Bariatric Surgery Bariatric surgery represents the most powerful and invasive tool for significant and sustained weight loss, says Christopher Thompson, MD, a professor of medicine at Harvard Medical School and the codirector of the Weight Management Center at Brigham and Womens Hospital in Boston

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In the enzymatic pathway, the lipoxygenase (LOX) family plays a central role: ALOX12 is essential for p53-mediated ferroptosis and serves as a key effector downstream of solute carrier family 7 member 11(SLC7A11) ( 2.2.3 Coordinated regulation by signaling pathways In periodontitis, aberrant activation of the Hippo-YAP pathway promotes iron accumulation and lipid peroxidation synergistically by upregulating TFRC and ACSL4 while downregulating GPX4, thereby accelerating ferroptosis-induced periodontal tissue damage ( Clinical evidence indicates that gingival tissue biopsies from periodontitis patients show significantly upregulated ACSL4 protein expression, and gingival crevicular fluid exhibits abnormally elevated concentrations of 4-HNE and MDA

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22. Stratakis CA, Kirschner LS & Carney JA