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At a glance Interaction type / pharmacokinetic (CYP3A4 inhibition) plus pharmacodynamic (additive BP lowering) Enzyme involved / CYP3A4 (primary route of amlodipine metabolism) Resveratrol dose linked to CYP inhibition / as low as 500 mg/day in human PK studies Amlodipine half-life / 30 to 50 hours, so enzyme inhibition effects accumulate slowly Main clinical risk / symptomatic hypotension, reflex tachycardia, worsened pedal edema Estrogenic concern / resveratrol binds estrogen receptor alpha

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(2023) ( Epub 2023/10/25 )