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Results: Significant reduction in modified MASI was observed in patients treated with topical and oral glutathione ( p =0.011) and ( p =0.007) respectively, while patients treated with topical or oral placebo had no response

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Specifically, RES reduced the levels of inflammatory factors, including TNF-, IL-1, and interferon-gamma (IFN-), and decreased the expression of the proteins Bax and caspase-3 through the mitochondrial-dependent apoptotic pathway (Xie et al., 2020)

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