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300 Intravenous Intrajejunal 250 200 Blood Glucose (mg/dL) 150 100 50 0 -30 -15 0 15 30 45 60 75 90 105 120 135 Time (min) A Fundamental Observation: Insulin Secretion is Greater with Oral Compared to IV Glucose Blood Glucose Plasma Insulin 300 IV/IJglucose 250 200 Plasma Insulin ( pmol/L) 150 100 50 0 -30 -15 0 15 30 45 60 75 90 105 120 135 Time (min) Adapted from McIntyre N, et al

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Tirzepatide has a more favourable tolerability profile based on current data