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While natural sources of quercetin are generally safe, concentrated doses in supplement form may have different effects and potential risks. Specifically, very high doses of quercetin have been investigated for their potential to cause kidney damage and hair loss (though research on hair loss as a direct consequence of excessive quercetin intake is limited)

Commonly observed features include: progressive catabolism of articular cartilage, subchondral bone sclerosis, and formation of osteophytes and subchondral cysts

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Prospective study of serum cysteine and cysteinylglycine and cancer of the head and neck, esophagus, and stomach in a cohort of male smokers

Ghozlan, A.A