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If dopamine is a central organizer of movement and motivated energy acquisition, and if it is biochemically continuous with endogenous morphine pathways that influence mitochondrial regulation, then Parkinsons disease may be interpreted as a breakdown in a primal dopamine-centered energy program rather than merely a transmitter deficit

10.1093/glycob/cwj115 Glycobiology 209 ZhangJ.De KoninckY

This approach makes theoretical sense

It acknowledges that there is no universal plan and instead places experimentation and continuous self-observation as central