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At the highest dose, participants lost an average of 20.9% of their body weight

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The pattern is consistent: palpitations cluster around dose increases, correlate with hydration status, and respond predictably to electrolyte management

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In OASIS-4, nearly three-quarters of participants on semaglutide experienced gastrointestinal (GI) side effectsmostly nausea and vomitingcompared to about 42% in the placebo group