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Its like a rubber bandyou pull it hard and it snaps back quickly. For that reason, clinicians typically counsel patients that GLP-1 medications are a long-term treatment, similar to medications for high blood pressure or diabetes
The redox effects of GSH or other thiol agents can be assessed by the use of irreversible thiol alkylating agents such as N-ethyl maleimide (NEM) which would form covalent bonds with cysteine residues and prevent further modification of these sites as has been analyzed in modulation of GABA- and glycine-evoked currents in rat retinal ganglion cells (24)
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