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2 3 The proposed mechanisms include promotion of angiogenesis (new blood-vessel formation), effects on the nitric-oxide system, and stimulation of fibroblast outgrowth and cell migration through signaling pathways such as FAK-paxillin

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The most common side effects include: Nausea and vomiting (especially in the first few weeks) Diarrhea or constipation Headache Fatigue Loss of appetite These side effects usually go away as the body adapts, but it is important to start with a low dose and gradually increase it