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As a result, data mining alone does not provide sufficient evidence to establish causality and primarily emphasizes the need for practitioner vigilance

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Excessive collagen deposition increases the mechanical stiffness of the tissue, which activates focal adhesion kinase (FAK) via integrins on the cell surface and induces the nuclear translocation of Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) as downstream signaling mediators (Thammawithan et al

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