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However, new therapies are under investigation, for example, mitapivat, a small-molecule allosteric activator of PK has shown to induce a clinically relevant hemoglobin increase and improvement in hemolytic parameters in a phase II clinical trial (Grace et al., 2019b)

Gorca A, Huk-Kolega H, Piechota A, Kleniewska P, Ciejka E, Skibska B

Pure compounds from Moringa extract improve insulin secretion in the pancreatic islets of mice

Since kidney function is reduced during AKI, activation of the urea cycle and subsequent urea generation together lead to a substantial rise in BUN 14,35