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Moreover, GA plays a crucial role in mitigating inorganic phosphate-induced vascular smooth muscle cell calcification by blocking the BMP2-Smad1/5/8 signaling pathway (Wang and Bao, 2020)

In the vasculature, GLP-1RAs and DPP-4 inhibitors mitigate LPS-induced endothelial permeability, inflammation, and microvascular thrombosis by activating AMPK and CaMKK, reducing adhesion molecule expression (VCAM-1, ICAM-1), and improving outcomes in septic shock

IB33001, INDIGO Biosciences, Inc.) according to the manufacturer

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