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Therefore, localized immunometabolic disturbances, particularly defective butyrate metabolism and dysregulated tryptophan catabolism, disrupt the Th17/Treg balance and compromise epithelial integrity in IBD, underscoring the gut microbiome and microbial metabolites as actionable therapeutic targets

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HF diabetic mice exhibited an obvious shift in the gut microbiome, resulting in a reduction in the abundance of genera Rikenellaceae , Lactobacillus , and Bacteroides and an increase in genera Streptococcus , Oscillospira , Ruminococcus , and Allobaculum vs ND-treated mice

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Roche for example paid $2.7bn to acquire privately held Carmot Therapeutics while AstraZeneca in-licensed an oral drug from Chinas Eccogene for $185m upfront (and $1.8bn of potential milestones)