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Finally, two studies reported that genetic variability in CD44 antigen might predispose patients to acetaminophen-induced liver injury at supra-therapeutic doses [106] or to acute liver failure after the drug overdose [100]

Ferreira et al., 2021)

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Some neurogenic stimuli, such as physical exercise, can partially revert the decrease of neurogenesis occurring during aging [208,209,210], while other neurogenic stimuli, though effective in the adult, are unable to elicit neurogenesis in aged models