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Although several studies supported the role of GIP as an enterogastrone (25, 64, 65), others challenged a role for GIP as an inhibitor of gastric acid secretion under physiological conditions (66, 67)

Because they slow digestion, common side effects may include nausea and vomiting

doi: 10.1093/jsxmed/qdad176 21 DastoraniMAghadavodEMirhosseiniNForoozanfardFZadeh ModarresSAmiri SiavashaniMet al

Low IGF-1 may lead to insulin resistance, diabetes symptoms, and cardiovascular disease

Updates include: GLP-1 receptor agonists preferred for patients with diabetes and MASH Clear referral to liver specialists when fibrosis risk is high Integration of fibrosis-4 (FIB-4) scoring into routine assessment Diabetes, liver disease, and obesity now sit within the same decision framework