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The lack of protection and repair capabilities can leave nerves vulnerable to damage

[2] For this reason, elevated serum homocysteine over 15 micromol/L and methylmalonic acid (MMA) over 0.271 micromol/L are considered better indicators of B 12 deficiency, rather than relying only on the concentration of B 12 in blood

The NAD + -salvage-pathway connection has positioned NNMT inhibition within the broader cellular-aging and sirtuin-pathway research framework, alongside NAD + precursors such as nicotinamide riboside and nicotinamide mononucleotide

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None of this makes the mechanism uninteresting