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Yet, some procarcinogens require phase I enzymes in order to become active carcinogens capable of binding DNA and forming cancer-causing DNA adducts

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(38) reported microglia and astrocytes overactivation, increase in proinflammatory cytokines, mitochondrial dysfunction, and abnormal neuronal morphology in the hippocampus of young and old mice subjected to 24 h of sleep deprivation, whereas treatment with urolithin A protected against these adverse effects

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