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43 In addition, genetic defects in DNA repair pathways may directly lead to the development of premature aging syndromes, including Werner syndrome, 44 Bloom syndrome, 45 Hutchinson-Gilford progeria syndrome 46 , and Cockayne syndrome

378 On the basis of the increased activity of -gal in senescent cells, a new prodrug, SSK1, which can be specifically cleaved by lysosomal -gal into cytotoxic substances and induce the apoptosis of senescent cells, thereby eliminating senescent cells, was developed

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Costs per user would decline over time, from $5,600 per person in 2026 to $4,300 per person in 2034, but are likely to be offset by increased uptake

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