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Effects of GLP-1 and GIP receptor agonists include: Stimulating insulin secretion in response to food (glucose-dependent) Reducing inappropriate glucagon release, lowering hepatic glucose output (GLP-1 enhances the sensitivity of alpha cells to glucose , resulting in more glucose-appropriate glucagon secretion) When blood glucose is high, insulin secretion is stimulated and glucagon secretion is inhibited

Huberman discussed retatrutide at length and clearly found the data compelling, but he explicitly did not endorse or recommend it

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However, my colleagues and I also found previously unidentified risks