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These medications work by slowing gastric emptying, improving insulin response, and most notably, reducing appetite

In the STEP 1 extension, people who stopped semaglutide regained 11.6 percentage points of body weight over 52 weeks, ending with an average net loss of 5.6% from baseline while lifestyle support continued (STEP 1 extension data)

The absence of needle-related complications and a reduced likelihood of allergic reactions contribute to their safety profile

(2011), who reported that intermittent energy restriction led to improvements in oxidative stress markers in overweight women 8

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