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Semaglutide trials reported 24-29% constipation rates while tirzepatide trials showed 12-27%
Upon higher magnification, hGLP-1R was observed at the plasma membrane of -cells in hGLP-1R islets, confirming proper sub-cellular localization ( Figures 7EG )
Market Expansion & Competition Rival GLP-1 pills are in late-stage development, including Eli Lillys orforglipron , which could be approved in 2026
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