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Le Clark Harvey Person Studies have shown that patients facing high costs are less likely to take medications as prescribed, more likely to abandon therapy, and more likely to delay or forego treatment, putting them at higher risk for expensive emergency room visits, avoidable hospitalizations, and poor health outcomes

The bupropion component can cause dry mouth, insomnia, and tremor in some patients

Foresta C, Ferlin A, Toni LD, Lana A, Vinanzi C, Galan A, et al

10.1007/978-981-10-3707-8_9 172 XiaY.ChenS.ZhuG.HuangR.YinY.RenW.et al (2018)

[35] This high requirement for NAD + results from the constant consumption of the coenzyme in reactions such as posttranslational modifications, since the cycling of NAD + between oxidized and reduced forms in redox reactions does not change the overall levels of the coenzyme