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Enhanced Energy Expenditure and Fat Oxidation Studies show AOD9604 increases overall energy expenditure and fat oxidation rates independent of direct -AR activation [1]

Additionally, GLP-1 analogs reduced energy expenditure, with only tirzepatide showing a significant decrease in the respiratory quotient (RQ) in MC4R KO mice

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The notion that astrocyte reactivity is somehow globally harmful per se and should therefore be blocked in its entirety is likely to do more harm than good and is no longer tenable