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Conclusions In recent years, parallel to the increase in clinical and survival benefits that we have obtained with the widespread use of OL-HDF over conventional HD, we have also witnessed a change in the profile of dialysis patients who are increasingly older and with more comorbidities, and continue to have problems associated with inflammation, oxidative stress, and excess cardiovascular morbidity and mortality

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Exogenous treatment of proline could enhance the expression of PR as well as HR-mediated programmed cell death (PCD), with similar results elucidated in homoserine- or threonine-mediated plant immunity to oomycete pathogens [72,114]

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