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J Diabetes Complications (2020) 34:107520

They found that although many regions of the brain have GLP-1 receptors, when the mice were dosed with the GLP-1R agonist semaglutide, the semaglutide ended up on only a fraction of the mouse brains GLP-1 receptors, mainly in the hypothalamus, brainstem, and septum

Some studies, though not conclusive, predict that tirzepatide may in fact be more potent than GLP-1 RAs at reducing weight

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