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Unknown Risks: Given its influence on fundamental metabolic processes (AMPK) and mTOR regulation, the long-term safety of chronic, supraphysiological MOTS-c administration is unknown and requires caution

Interest in Epitalon has grown in part due to its visibility on biohacking forums, and partially due to the resurgence of peptide therapeutics in both academic and clinical spaces

Cheng T, Xu Z, Ma X (2022) The role of astrocytes in neuropathic pain

Jul 2010;18(7):1354-1359

However, although leptin supplementation is effective for patients with congenital leptin deficiency, leptin has little effect on weight reduction