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Orally administration of valsartan (1040 mg/kg/day, 4 weeks) promotes the hippocampus neurogenesis and the BDNF expression, exerting an antidepressant-like effect, which may be one of the mechanisms for its antidepressant (191)

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The main ongoing challenge is maintaining adequate nutrition despite reduced appetite

Oral methylcobalamin gets converted into adenosylcobalamin, and regenerates some of the methylcobalamin