Based on published data: Tirzepatide: Highest average HbA1c reduction in trials Semaglutide: Strong glucose control + proven cardiovascular benefit Dulaglutide & Liraglutide: Reliable, well-studied options Oral semaglutide: Effective non-injectable alternative But 'best' depends on: Baseline HbA1c, Cardiovascular risk, Weight goals, Tolerability, Convenience, and Physician guidance
Nevertheless, the involvement of an hypomethylation cannot be ruled out, because in vitro studies suggest that a low concentration of homocysteine specifically inhibits endothelial cell regeneration and directly activates quiescent vascular smooth muscle cells through a mechanism involving decreased carboxymethylation of p21 ras (Lee and Wang, 1999
Foods such as fruits, vegetables, legumes, whole grains, nuts, and seeds should form the backbone of your diet
doi: 10.1159/000506879CrossRefGoogle ScholarPubMed Chanson, P., Arnoux, A., Mavromati, M., Brailly-Tabard, S., Massart, C., Young, & J., for the VARIETE Investigators (2016)
It aggravates various cardiovascular (CV) risk factors and is, per se, an independent risk factor for CV mortality