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In practical terms, they act as chemical messengers: they bind to receptors on cells, interact directly with proteins, or prompt the body to release a specific hormone, then let that hormone carry out the actual work

A perfectly chosen site, used repeatedly in the same spot, can become less effective than a rotated thigh site

In contrast, MTX significantly suppresses the Teff subsets in most tissues, maintaining the disease in a quiescent state, but the risk of relapse may be higher after drug withdrawal (111)

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Bian, T., et al