Despite aggressive marketing promoting these drugs as safe and effective, GLP-1 medications have been linked to severe health risks, including gastroparesisa condition where the stomach is paralyzed, leading to long-term gastrointestinal issues
Risks include weight gain, hypoglycemia, pancreatitis, cirrhosis, heart disease, cancer, mental health issues, and an increased likelihood of accidents
These alterations of renal energy and substrate metabolism may result from inherent abnormalities, including genetic defects, attempts of the kidneys to respond to environmental stressors, such as high-salt intake, or a combination of internal and external factors
Acetoacetate itself may be sourced from mitochondrial ketogenesis or peroxisomal fatty acid oxidation, although the former scenario is unlikely because ketogenesis is rather inactive in cancer cells 256,257
Desired Concerns: The concerns that are to be addressed play a major role in evaluating the cost