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Wiley Interdiscip Rev Nanomed Nanobiotechnol

Many biologic-based therapeutics leverage these pathways, either by enhancing NO signaling and cGMP-mediated vasodilation or by attenuating Ca-dependent vasoconstriction, thereby exerting antihypertensive and cardioprotective effects

Wettergren A, Schjoldager B, Mortensen PE, et al

Severe dehydration and electrolyte imbalance can lead to shock or coma and may be life-threatening

It's worth noting, however, that the weight-loss achieved with oral therapies is acknowledged to be less than that seen with the current injectable GLP-1-based therapies, and their convenient dosing offers the prospect of early intervention and long-term disease management