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Hebbian plasticity requires compensatory processes on multiple timescales

In clinical advancement, strategies with more realistic value include local delivery or use as adjuvant therapy, rather than relying on long-term systemic exposure

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We previously produced the App NL-G-F/NL-G-F -KI ( App NL-G-F ) mouse strain using genomic DNA of introns 15 to 17 of mouse APP, which humanized the A sequence, and introduced KM670/671NL (Swedish), I716F (Iberian), and E693G (Arctic) mutations 41

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