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It enrolled 17,604 adults aged 45 or older with a body mass index (BMI) of 27 kg/m2 or greater and preexisting CVD (prior MI, prior stroke or peripheral artery disease) without diabetes

Adjust treatment dosage if necessary under medical supervision, since higher doses are known to cause more adverse reactions than lower ones

The different receptor profile and biased agonism of tirzepatide produce a somewhat different side effect pattern

Surgical options need significant upfront payment, while semaglutides ongoing medication costs require careful financial planning

Patients with heart failure, kidney disease, or other conditions requiring fluid restriction should follow their healthcare provider's specific guidance