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In a subsequent study, they found superior efficacy by increasing GCGR tone in dualAGs, but with adverse consequences in glucose control 7 , emphasizing the importance of developing a balanced activity across GLP-1R and GCGR

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In the context of a shifting paradigm in type 2 diabetes management and the current limited understanding of the potential impact on retinal risk, it is encouraging that there were no inter-agent differences in retinopathy complications in this head-to-head comparison, the study authors wrote in their paper

In homozygotes, microglial and astrocyte activation appeared at 12 months, neuronal loss in the hippocampus and entorhinal cortex at 24 months, and synaptic loss at 8 months

PMID: 41318751 14 Primary carnitine deficiency with severe acute hepatitis following rotavirus gastroenteritis