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Once inside, they: Reduce neuroinflammation (inhibit NFB, microglial activation) Boost synaptic plasticity (enhance neuron connectivity) Improve glucose uptake (support brain energy metabolism) Local GLP-1 from neurons likely doesnt drive these effectspharmacological action dominates

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investigated that dulaglutide prevented diabetic HF and myocardial metabolic remodeling by impeding mitochondria fragmentation [119]